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In March, a team led by Sinclair published research linking frailty and other diseases of aging to a decline in the production of blood vessels that feed the muscles. In elderly mice, the team showed that administering a compound called nicotinamide mononucleotide, or NMN, improved blood ?ow, increased endurance and reversed signs of aging. It did so by boosting the very cellular processes that are, in younger animals, spurred by vigorous exercise.

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